Illustration DIGIT-BIO

News

InsiliCow DiGIT-BIO, © INRAE
Article

05 April 2024

Redaction: Marjorie Domergue

The inSiliCow simulator: a virtual dairy farm to improve real-farm management

By applying the concept of the digital twin at the scale of a dairy farm, the inSiliCow project will develop a multi-scale simulation tool to aid on-farm decision-making with regard to farming practices for dairy cows. The inSiliCow project is a flagship ‘digital twin’ project for the Metaprogramme DIGIT-BIO.
HepatO'Twin © Julos, Freepik
Article

05 April 2024

Redaction: Marjorie Domergue

HepatO’twin: a digital twin to investigate the effects of food contaminants on the hepatic metabolism

The HepatO'twin project will put the concept of the digital twin to use in exploring the effects of food contaminants on the liver’s metabolism. This will allow us to advance understanding of the contribution made by diet and exposure to food contaminants to the risk of developing metabolic diseases.
Booklet of projects DIGIT-BIO
Article

06 October 2023

Redaction: Marjorie Domergue

Overview of projects supported by DIGIT-BIO

Since its launch in March 2021, DIGIT-BIO has funded 6 interdisciplinary consortia and 14 exploratory projects in the field of digital biology. Find an overview of the actions supported by the metaprogramme.
Illustration adn
Article

18 September 2023

Redaction: Com

An interdisciplinary network for 3D genomics

in the nucleus of a cell, the three-dimensional conformation of the genome has a major impact on how it functions. A better understanding of the links between the 3D structure of the genome and its functioning represents a methodological challenge and requires dialogue between different disciplines
Article

18 September 2023

Redaction: Com

A new tool for exploring the multi-regulator and multi-scale network controlling plant architecture

To maintain the agronomic performance of plants in increasingly stressful environments, it is necessary to have a systemic vision of their adaptation mechanisms, particularly their architectural development, i.e. the initiation and development of new organs.
Article

18 September 2023

Redaction: Com

Modeling decision algorithms for root development in heterogeneous environments

To survive, plants must take up water and many nutrients from the soil. These resources are unevenly distributed and plants must explore the soil to find them. This exploration requires the extension of roots, which is a development that comes at a cost for the plant.
Article

18 September 2023

Redaction: Com

Predicting plant phenotypes under combined stress

Climate change, the scarcity of certain natural resources and the need to reduce agricultural inputs have increased the number and diversity of situations that agronomists need to understand. They need plant models with extensive predictive capability and capable of taking into account complex environmental conditions, where different constraints (stresses) come into play at the same time.
cultures d'arabidopsis
Article

18 September 2023

Redaction: Com

Predicting plant response to combined stresses (CO2 and Heat)

Plants are constantly threatened by biotic and abiotic stresses, especially in the current context of climate change. The complexity of the stress response involves different levels of biological organisation, from genomes to metabolites.
Article

18 September 2023

Redaction: Com

Predicting the response of plants exposed to chronic thermal stress

Climate change is characterised not only by variable and extreme intensities of the main climatic factors but also by an increased frequency of extreme events, such as heat waves, which are highly detrimental to field crop yields and harvest quality.
Article

18 September 2023

Redaction: Com

Visualising fish oocytes using AI and 3D imaging

In the natural environment as well as in fish farming, the process of formation and maturation of female gametes (oogenesis) is essential for reproductive success.
Article

18 September 2023

Redaction: Com

Application of machine learning and deep learning to improve animal genomic selection

The development of genomic selection - and other "omics" analyses such as metagenomics, transcriptomics, metabolomics and proteomics - now makes it possible to characterise animals using thousands of measurements. This massive data is integrated into models to predict production traits with the highest possible degree of accuracy.
Article

23 January 2024

Redaction: Com

Analysing biological networks of mixed-type data with copula models

Integrative biology is based on the study of complex biological networks. Understanding the plasticity of biological interaction networks due to phenotypic, environmental or interventional variability is an important challenge in fields as diverse as genomics or human nutrition. Such studies often include comparisons between contrasting groups, including variables of various natures (continuous, counts, binary, etc.). These so-called "mixed-type" data can be difficult to analyse in a unified way. While multivariate probabilistic models provide a robust framework for inferring interrelationships among continuous variables, an analogous model for mixed-type data has yet to be defined.