DIGIT-BIO metaprogramme

DIGIT-BIO

Digital biology to understand and predict biological systems

.

Merlin-Lightpainting---PEXELS
article

31 August 2026

By: Domergue Marjorie

Knowledge Transfer for Modelling at Organism Scale

The KOMOD consortium project seeks to organize a new multidisciplinary community working on the modelling of complex organisms of agronomic or zootechnical interest. Its core focus is the formalization and encoding of biological information to facilitate the transfer and reconstruction of complex biological processes and encourage convergence between the plant and animal research communities through shared modelling methods and frameworks.
Illustration thèse confinancée

Thesis by Julien Kossi Kowou (2025 - , UMR GABI). This PhD project aims to develop statistical analysis methods to explore inter-species genetic diversity.

@Olivier FILANGI

The SEED project expands the Metabolomic Semantic Data Lake (MSD), an electronic infrastructure that combines the Semantic Web with Big Data technologies to enable large-scale processing of the scientific literature on metabolomics. First developed to improve access to knowledge on the links between the metabolism and human health, this infrastructure has now been adapted to include plant metabolisms. SEED will refine its use of artificial intelligence, enabling publications to be annotated automatically through the use of ontologies. The project will also expand the range of sources included in the data lake and will draw on four case studies to validate and illustrate the new associations discovered between metabolites, biomarkers and plants.

Thesis by Adèle Coppel (2025 - 2028, LIPME). The objective of this PhD project is to investigate, through modelling approaches, the role of wind in the modulation of plant immune responses and to identify molecular actors involved in the variability of resistance associated with acclimation and sensitization.

Our goals

The quantitative and qualitative explosion of data in biology, combined with the development of new tools for processing and analysing these data, is revolutionising research in the life sciences. This development opens up new perspectives for better understanding the functioning of biological systems and predicting their behaviour.

The metaprogramme Digit-Bio aim to support research at the interface between computational / engineering sciences and life sciences (biology, physics, chemistry or environmental sciences), in order to:

  • Understand the functioning and predict the behaviour of biological systems
  • Anticipate the impact of stresses on these systems, reason out their management and develop levers for action.  In the medium term, the ambition is to develop a small number of projects for in silico monitoring of biological systems, based on the concept of the "digital twin".

 

Axis schématic DIGIT-BIO © INRAE
© INRAE