Multiscale mathematical modeling of oogenesis in fish

Summary

This PhD thesis is dedicated to the understanding and quantification of the ovarian dynamics of fish models (e.g. medaka, zebrafish). Given its cyclical nature, the ovary presents a deep cellular remodelling of which the regulation is essential for gamete maturation and reproductive success. The lack of observable data in real time at the level of cell population distribution (enumeration, cell type, etc.) is a recurrent difficulty for the comprehension of cellular dynamics in ovaries. The aim of the thesis is to construct and calibrate a mathematical model integrating all gamete maturation dynamics (and regulation) throughout the lifetime of the fish, by using notably the new data obtained through recent advances in 3-D imaging. We will pay particular attention to demonstrating how this model will improve predictions of the effect of environmental perturbations on the reproductive function over a fish lifetime. This thesis will lead to new research results in the fish reproduction field and will develop generic approaches for structured population modelling.

Contact

• Louis Fostier (UMR PRC)
• Linkedin

Publications

Frédérique Clément, Louis Fostier, Romain Yvinec. Well-posedness and bifurcation analysis of a size-structured population model: Application to female gametes dynamics. 2024. ⟨hal-04699357⟩